A postdoctoral and PhD position is available in Dr. Subramaniam lab beginning 2025 in the Stiles-Nicholson Brain Institute (SNBI) at the Florida Atlantic University (FAU).
A PhD candidate must be highly driven and ambitious and have a master's degree in any life sciences subject. A research background in cellular and molecular neuroscience is advantageous. The candidate must possess strong communication skills and the ability to collaborate with an interdisciplinary team with a keen interest in teaching undergraduates. The candidate must have the intrinsic solid drive and the ability to uncover underlying pathways that influence cellular functions and neurodegenerative disease.
A postdoc candidate should have a PhD in cellular and molecular understanding of the biological process using cell and animal model. Neuroscience or closely-related disciplines with particular focus on neurodegenerative disease such as Alzheimer, Huntington, or Parkinson is a plus. The candidate should have demonstrated ability of research work through peer-reviewed publications. Postdoc applicants with experience in mouse handling, stereotaxic surgery, and brain imaging analysis are given priority.
Dr. Subramaniam's lab uses cell and animal models combined with cellular, molecular, signaling and system biology approaches to investigate neurodegenerative disease mechanisms. The SNBI-FAU comprises distinguished faculties, cutting-edge facilities, and is situated on campus, encompassing the Max Planck Institute and the UF-Scripps Research Institute, which provide exceptional opportunities for academic and collaborative studies. Jupiter, Florida, USA, has a population of ~62,000 and is located in Palm Beach County, which is considered one of the nicest places to live in Florida. Jupiter has many restaurants, coffee shops, parks, and wonderful beaches. Jupiter's public schools receive excellent ratings.
Please review the following examples of publications. Interested candidates please send a cover letter, full resume, and career goals to Dr. Srini Subramaniam ssubramaniam@fau.edu
1. Subramaniam S, Sixt KM, Barrow R, Snyder SH. Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity. Science. 2009; PMID: 19498170.
2. Pryor WM, Biagioli M, Shahani N, Swarnkar S, Huang WC, Page DT, MacDonald ME, Subramaniam S. Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease. Science Signaling. 2014. PMID: 25351248.
3. Shahani N, Swarnkar S, Giovinazzo V, Morgenweck J, Bohn LM, Scharager-Tapia C, Pascal B, Martinez-Acedo P, Khare K, Subramaniam S. RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatum. Science Signaling. 2016. PMID: 27902448; PMCID: PMC5142824.
4. Sharma M, Jarquin UNR, Rivera O, Kazantzis M, Eshraghi M, Shahani N, Sharma V, Tapia R, Subramaniam S. Rhes, a striatal-enriched protein, promotes mitophagy via Nix. Proc Natl Acad Sci U S A. 2019; PMID: 31676548.
5. Eshraghi M, Ramirez-Jarquin UN, Shahani N, Nuzzo T, De Rosa A, Swarnkar S, Galli N, Rivera O, Tsaprailis G, Scharager-Tapia C, Crynen G, Li Q, Thiolat ML, Bezard E, Usiello A, Subramaniam S. RasGRP1 is a causal factor in the development of l-DOPA-induced dyskinesia in Parkinson's disease. Science Advances. 2020; PMID: 32426479.
6. Eshraghi M, Karunadharma PP, Blin J, Shahani N, Ricci EP, Michel A, Urban NT, Galli N, Sharma M, Ramirez-Jarquin UN, Florescu K, Hernandez J, Subramaniam S. Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease. Nature Communications. 2021; PMID: 33674575.
7. Ramirez-Jarquin UN, Sharma M, Shahani N, Li Y, Boregowda S, Subramaniam S. Rhes protein transits from neuron to neuron and facilitates mutant huntingtin spreading in the brain. Science Advances. 2022; PMID: 35319973.
8. Ramirez-Jarquin UN, Sharma M, Zhou W, Shahani N, Subramaniam S. Deletion of SUMO1 attenuates behavioral and anatomical deficits by regulating autophagic activities in Huntington disease. Proc Natl Acad Sci U S A. 2022; PMID: 35086928.
9. Rivera O, Sharma M, Dagar S, Shahani N, Ramlrez-Jarquln UN, Crynen G, Karunadharma P, McManus F, Bonneil E, Pierre T, Subramaniam S. Rhes, a striatal enriched protein, regulates post-translational small-ubiquitin-like-modifier (SUMO) modification of nuclear proteins and alters gene expression. Cell Mol Life Sci. 2024; PMID: 38589732.
10. Dagar S, Sharma M, Tsaprailis G, Tapia CS, Crynen G, Joshi PS, Shahani N, Subramaniam S. Ribosome Profiling and Mass Spectrometry Reveal Widespread Mitochondrial Translation Defects in a Striatal Cell Model of Huntington Disease. Mol Cell Proteomics. 2024; PMID: 38447791.
Regarding previous work of Dr. Subramaniam's lab, please visit https://www.ncbi.nlm.nih.gov/myncbi/srinivasa.subramaniam.1/bibliography/public/
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