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Neurosignaling Lab

Our lab focuses on identification and characterization of signaling networks in neurodegenerative diseases with a goal of developing clinical therapeutics.

News & Events

Research Focus

Our lab is dedicated to studying the intricate signaling networks involved in neurodegenerative diseases. We aim to identify and characterize these networks to develop targeted clinical therapeutics. Our team is committed to making significant contributions to the understanding and treatment of these challenging conditions. We are passionate about our research and strive to make a positive impact on the lives of patients and their families.​

Latest Publications

Rhes protein transits from neuron to neuron and facilitates mutant huntingtin spreading in the brain

Rhes moves and transports the HD protein, polyglutamine-expanded huntingtin (mHTT), via tunneling nanotube (TNT)-like membranous protrusions between cultured neurons. However, similar intercellular Rhes transportation in the intact brain was unknown. Here we show Rhes is a first striatum-enriched protein demonstrated to move and transport mHTT between neurons and brain regions, providing new insights into interneuronal protein transport in the brain. PMC8942366

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